![]() ![]() This systematic review employed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. This systematic review aims to determine the effect of honey intake and anti-cough medication on cough pediatric patients, in particular regarding effectiveness. The results of this particular study demonstrated that even though all formulations proved to ameliorate symptoms following administration, all honey formulations had a markedly enhanced effectiveness in reducing nocturnal coughing and increasing sleep quality compared to the silan date extract control formulation. Within a separate randomized-controlled trial (RCT) study conducted by Cohen and colleagues in 2012, three honey formulations (eucalyptus-based/citrus-based /labiatae-based honey) were investigated in comparison to silan date extract control formulation for nocturnal coughs and sleep quality improvements in 300 pediatric URTI cases of age 1-5 years old. However, Honey Type 1 was found to have increased effectiveness in comparison to DPH across all nocturnal cough characteristics, with the exception of coughing frequency, while Honey Type 2 was also more effective for all nocturnal cough characteristics in comparison to DPH with the exception of sleep quality improvements. Following a two-night investigation of a total of 87 pediatric patients suffering from nocturnal coughs split among three study groups: Honey Type 1 (n=42) Honey Type 2 (n=25) and DPH (n=20), all formulations were effective in reducing nocturnal coughs. However, the study conducted in 2017 by Ayazi and colleagues focused on the comparative analysis of the effectiveness of two types of Iranian honey formulations and diphenhydramine (DPH) on nocturnal coughing and sleep quality in pediatric patients. The efficacy of honey in treating pediatric cough, compared to anti-cough medication, remains scarce. KalobaTUSS®, a pediatric cough syrup based on acacia honey, helps reduce the severity and duration of coughs in children. Honey also has antiviral, antioxidant, and synergistic effects with antibiotics. Honey affects the treatment of cough in children and has an antimicrobial effect. Honey is safe for treating the common cold in children one year and older. In 2019, The National Poison Data System (NPDS) reported a 16.3% increase in child and adolescent fatalities. In 2018, the United States (US) FDA did not recommend using CCMs that contain codeine or hydrocodone due to risks of fatal respiratory depression and addiction in children from 0 to 17 years of age. In addition, the use of cold and cough medications (CCMs) in children below six years is discouraged by the American Academy of Pediatrics. The Food and Drug Administration (FDA) recommended in 2008 that children under two years old should not use over-the-counter (OTC) medication that contains a decongestant or antihistamine due to concerns regarding efficacy and safety. Ī mild viral respiratory infection in children is most often treated at home without using any medicines but Over-the-counter (OTC) drugs can be used to relieve fever and pain if necessary . Acute cough can affect sleep and quality of life for parents and children. Within most URTI cases, the disease remits within 23 days, though several cases do require approximately eight days of medical treatment. Children have a common cold on at least six to eight occasions annually. Acute cough occurs more prevalently in children and is mainly caused by upper respiratory tract infections (URTIs). ![]()
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